Mycobacterium avium Subspecies paratuberculosis Recombinant Proteins Modulate Antimycobacterial Functions of Bovine Macrophages

@inproceedings{Bannantine2015MycobacteriumAS,
  title={Mycobacterium avium Subspecies paratuberculosis Recombinant Proteins Modulate Antimycobacterial Functions of Bovine Macrophages},
  author={John P Bannantine and Judith R Stabel and Elizabeth M Laws and Maria Clara D. Cardieri and Cleverson D. Souza and Srinand Sreevatsan},
  booktitle={PloS one},
  year={2015}
}
It has been shown that Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) activates the Mitogen Activated Protein Kinase (MAPK) p38 pathway, yet it is unclear which components of M. paratuberculosis are involved in the process. Therefore, a set of 42 M. paratuberculosis recombinant proteins expressed from coding sequences annotated as lipoproteins were screened for their ability to induce IL-10 expression, an indicator of MAPKp38 activation, in bovine monocyte-derived… CONTINUE READING
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