Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response.

@article{Nigou2002MycobacterialLM,
  title={Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response.},
  author={J{\'e}r{\^o}me Nigou and Martine Gilleron and M. Diaz de Rojas and Luis Fernando Garc{\'i}a and Martin Thurnher and Germain Puzo},
  journal={Microbes and infection},
  year={2002},
  volume={4 9},
  pages={945-53}
}
The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis. 

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