Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling.

@article{Tapping2003MycobacterialLM,
  title={Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling.},
  author={Richard I. Tapping and Peter S. Tobias},
  journal={Journal of endotoxin research},
  year={2003},
  volume={9 4},
  pages={264-8}
}
Mycobacteria and their cell wall component lipoarabinomannan (LAM) have recently been established as agonists for TLR2. Our transfection studies with single and pairwise combinations of TLRs 1, 2, 6 and 10 reveal that only TLR1 and TLR2 together mediate strong activation of NF-kappaB-driven luciferase activity in response to LAM. Co-operative signaling by TLR1 and TLR2 is observed using either non-capped or mannose-capped LAM as a stimulus. Moreover, we have found that phosphatidylinositol… CONTINUE READING

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