Mycobacterial infection of macrophages results in membrane-permeable phagosomes.

  title={Mycobacterial infection of macrophages results in membrane-permeable phagosomes.},
  author={Rachel Teitelbaum and Michael Cammer and Michael L. Maitland and Nancy E. Freitag and John S Condeelis and Barry R. Bloom},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 26},
Cell-mediated immunity is critical for host resistance to tuberculosis. T lymphocytes recognizing antigens presented by the major histocompatibility complex (MHC) class I and class II molecules have been found to be necessary for control of mycobacterial infection. Mice genetically deficient in the generation of MHC class I and class Ia responses are susceptible to mycobacterial infection. Although soluble protein antigens are generally presented by macrophages to T cells through MHC class II… CONTINUE READING