Mycobacterial disease in patients with rheumatic disease

  title={Mycobacterial disease in patients with rheumatic disease},
  author={Jakko van Ingen and Martin J. Boeree and P N Richard Dekhuijzen and Dick van Soolingen},
  journal={Nature Clinical Practice Rheumatology},
This Review focuses on the emergence of mycobacterial disease in patients undergoing treatment for rheumatic disease with four new drug classes—tumor necrosis factor (TNF) inhibitors, human interleukin (IL)-1 receptor antagonists, anti-CD20 antibodies and CD4+ T-cell costimulation modulators—collectively referred to as biologic agents. Mycobacterial disease is a major cause of severe infection in patients undergoing anti-TNF therapy. Reports are now emerging of an association between… CONTINUE READING
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