Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice.

  title={Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice.},
  author={Andr{\'e} L. C. Moreira and Liana Georgieva Tsenova and Melles Haile Aman and Linda-Gail Bekker and Sherry Freeman and Bande Mangaliso and Ulf Schroeder and Jaishree Jagirdar and William Rom and Michael G Tovey and Victoria H. Freedman and Gilla Kaplan},
  journal={Infection and immunity},
  volume={70 4},
To control tuberculosis worldwide, the burden of adult pulmonary disease must be reduced. Although widely used, Mycobacterium bovis BCG vaccination given at birth does not protect against adult pulmonary disease. Therefore, postexposure vaccination of adults with mycobacterial antigens is being considered. We examined the effect of various mycobacterial antigens on mice with prior M. tuberculosis infection. Subcutaneous administration of live or heat-treated BCG with or without lipid adjuvants… CONTINUE READING


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