Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish.

@article{Chen2016MycobacterialWD,
  title={Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish.},
  author={Zhenkang Chen and Yangbo Hu and Bridgette M Cumming and Pei Lu and Lipeng Feng and Jiao-yu Deng and Adrie J C Steyn and Shiyun Chen},
  journal={Cell reports},
  year={2016},
  volume={16 9},
  pages={2512-24}
}
During the course of infection, Mycobacterium tuberculosis (Mtb) is exposed to diverse redox stresses that trigger metabolic and physiological changes. How these stressors are sensed and relayed to the Mtb transcriptional apparatus remains unclear. Here, we provide evidence that WhiB6 differentially regulates the ESX-1 and DosR regulons through its Fe-S cluster. When challenged with NO, WhiB6 continually activates expression of the DosR regulons but regulates ESX-1 expression through initial… CONTINUE READING
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Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish

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Cell Reports (2016), • 2016

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