Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

  title={Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways},
  author={Estelle Marion and Ok-Ryul Song and Thierry Christophe and J{\'e}r{\'e}mie Babonneau and Denis Fenistein and Jo{\"e}l Eyer and Frank Letournel and Daniel Henrion and Nicolas Clere and Vincent Paill{\'e} and Nathalie C. Gu{\'e}rineau and Jean-Paul Saint Andr{\'e} and Philipp Gersbach and Karl-Heinz Altmann and Timothy P Stinear and Yannick Comoglio and Guillaume Sandoz and Laurence Preisser and Yves Delneste and Edouard Yeramian and Laurent Marsollier and Priscille Brodin},
Mycobacterium ulcerans, the etiological agent of Buruli ulcer, causes extensive skin lesions, which despite their severity are not accompanied by pain. It was previously thought that this remarkable analgesia is ensured by direct nerve cell destruction. We demonstrate here that M. ulcerans-induced hypoesthesia is instead achieved through a specific neurological pathway triggered by the secreted mycobacterial polyketide mycolactone. We decipher this pathway at the molecular level, showing that… CONTINUE READING
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EMA401-003 study group

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