Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions.

@article{Conrad2017MycobacterialES,
  title={Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions.},
  author={William H. Conrad and Morwan M. Osman and Jonathan K Shanahan and Frances Chu and Kevin K. Takaki and James R Cameron and Digby Hopkinson-Woolley and Roland Brosch and L. Ramakrishnan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 6},
  pages={1371-1376}
}
Mycobacterium tuberculosis and Mycobacterium marinum are thought to exert virulence, in part, through their ability to lyse host cell membranes. The type VII secretion system ESX-1 [6-kDa early secretory antigenic target (ESAT-6) secretion system 1] is required for both virulence and host cell membrane lysis. Both activities are attributed to the pore-forming activity of the ESX-1-secreted substrate ESAT-6 because multiple studies have reported that recombinant ESAT-6 lyses eukaryotic membranes… CONTINUE READING
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