Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis.

@article{Koets2006Mycobacterial7K,
  title={Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis.},
  author={Ad P Koets and Aad C. Hoek and Merel Langelaar and Marije Overdijk and Wiebren J. Santema and Peter Franken and Willem van Eden and Victor P.M.G. Rutten},
  journal={Vaccine},
  year={2006},
  volume={24 14},
  pages={
          2550-9
        }
}
Paratuberculosis is a chronic granulomatous inflammation of the small intestine of cattle and other ruminants, caused by infection with Mycobacterium avium ssp. paratuberculosis (MAP). The disease can be found in ruminant herds worldwide, causing substantial economic losses at farm level due to premature culling and production losses. In previous studies, it has been shown that immune responses to recombinant MAP Hsp70 proteins were predominantly cell mediated. As protective immunity to the… CONTINUE READING

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