Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.

@article{PradosRosales2011MycobacteriaRA,
  title={Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.},
  author={Rafael Prados-Rosales and Andr{\'e}s Baena and Luis River{\'o}n Mart{\'i}nez and Jos{\'e} Luis Luque-Garc{\'i}a and Rainer Kalscheuer and Usha Veeraraghavan and Carmen Camara and Joshua D Nosanchuk and Gurdyal S Besra and Bing Chen and Juan M. Carballo Jimenez and Aharona Glatman-Freedman and William Robert Jacobs and Steven A. Porcelli and Arturo Casadevall},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 4},
  pages={1471-83}
}
Bacteria naturally release membrane vesicles (MVs) under a variety of growth environments. Their production is associated with virulence due to their capacity to concentrate toxins and immunomodulatory molecules. In this report, we show that the 2 medically important species of mycobacteria, Mycobacterium tuberculosis and Mycobacterium bovis bacille Calmette-Guérin, release MVs when growing in both liquid culture and within murine phagocytic cells in vitro and in vivo. We documented MV… CONTINUE READING

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