Mycobacteria in Crohn’s disease: how innate immune deficiency may result in chronic inflammation

@article{Lalande2010MycobacteriaIC,
  title={Mycobacteria in Crohn’s disease: how innate immune deficiency may result in chronic inflammation},
  author={Jean-Daniel Lalande and M. Behr},
  journal={Expert Review of Clinical Immunology},
  year={2010},
  volume={6},
  pages={633 - 641}
}
Crohn’s disease (CD) is often considered to be an autoimmune condition or, alternatively, an autoinflammatory condition, based on the observation of host-directed inflammatory processes. However, the underlying basis of this deleterious inflammatory response remains elusive. Recent findings from genetic and genomic studies have altered the perspective on the pathogenesis of CD, hinting at defects in innate immune sensing of intracellular bacteria and the handling of these organisms through… Expand
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