Mycobacteria in Crohn’s disease: how innate immune deficiency may result in chronic inflammation

@article{Lalande2010MycobacteriaIC,
  title={Mycobacteria in Crohn’s disease: how innate immune deficiency may result in chronic inflammation},
  author={Jean-Daniel Lalande and Marcel A. Behr},
  journal={Expert Review of Clinical Immunology},
  year={2010},
  volume={6},
  pages={633 - 641}
}
Crohn’s disease (CD) is often considered to be an autoimmune condition or, alternatively, an autoinflammatory condition, based on the observation of host-directed inflammatory processes. However, the underlying basis of this deleterious inflammatory response remains elusive. Recent findings from genetic and genomic studies have altered the perspective on the pathogenesis of CD, hinting at defects in innate immune sensing of intracellular bacteria and the handling of these organisms through… 
Inflammatory bowel disease
TLDR
This special focus issue of Expert Review of Clinical Immunology provides an overview of the current concepts and controversies regarding the pathogenesis, current and future therapeutic approaches, and the course of IBD.
Defective innate immunity in inflammatory bowel disease: a Crohn's disease exclusivity?
  • D. Marks
  • Medicine, Biology
    Current opinion in gastroenterology
  • 2011
TLDR
The demonstration of impaired acute inflammation in Crohn's disease provides a novel mechanism for its pathogenesis, with diminished macrophage cytokine production and neutrophil recruitment leading to reduced bacterial clearance.
The vesicle-associated function of NOD2 as a link between Crohn’s disease and mycobacterial infection
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Findings on NOD2 interactions and functions provide the missing pieces in the puzzle of a NOD1-mediated mechanism common for mycobacterial infections and CD and Implications of these new findings for the development of a better understanding and treatments of CD and myc Cobacterial infections are discussed.
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The majority of recent studies support a role for the ability of intestinal pathogens to promote chronic inflammation in individuals with genetic susceptibility and/or other environmental factors which remain to be identified.
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The important aspects of NOD2 and non-NOD2 mediated effects of MDP for the development of CD are highlighted, as well as how alterations in these pathways might translate into the developed of new therapeutic strategies.
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TLDR
Complex segregation analysis study suggests an oligogenic model of leprosy susceptibility stating that the patients carry susceptible allele's loci, and SNPs within and outside coding sequences are under intense examination for possible associations or mechanistic links to disease.
A Potential ‘Curative’ Modality for Crohn’s Disease---Modeled after Prophylaxis of Bovine Johne’s Disease
  • R. E. Click
  • Medicine
    Mycobacterial diseases : tuberculosis & leprosy
  • 2012
A naturally occurring, gastrointestinal disorder of ruminants (Johne’s disease) is a chronic, debilitating, lethal disease. The causative agent is Mycobacterium avium subspecies paratuberculosis
Successful treatment of asymptomatic or clinically terminal bovine Mycobacterium avium subspecies paratuberculosis infection (Johne's disease) with the bacterium Dietzia used as a probiotic alone or in combination with dexamethasone
TLDR
The goal of the present investigations was to design protocols that have applicability for IBD patients, and Dietzia was found safe for cattle of all ages and for normal and immunodeficient mice.
OPINION Gastrointestinal infection as a trigger for inflammatory bowel disease
TLDR
The majority of recent studies support a role for the ability of intestinal pathogens to promote chronic inflammation in individuals with genetic susceptibility and/or other environmental factors which remain to be identified, including subsets of commensal microflora.
POTENTIAL PROINFLAMMATORY ROLE OF VEGF IN PATIENTS WITH CROHN’S DISEASE
TLDR
It is believed that altered p16 and p53 induce enhanced VEGF expression and implicates enhanced production of pro-infl ammatory TNF-α and IL-6 and further facilitate development of type 1/17 immune response.
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