Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders

  title={Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders},
  author={Graham A W Rook and Vc Adams and John Hunt and Rebecca M Palmer and Roberta Lopes de Castro Martinelli and Laura Rosa Brunet},
  journal={Springer Seminars in Immunopathology},
In the rich, developed parts of the world there has been a steady and simultaneous increase in at least three groups of disease: (1) allergies, (2) inflammatory bowel diseases (IBD; e.g. Crohn’s disease and ulcerative colitis) and (3) autoimmunity (e.g. type 1 diabetes and multiple sclerosis). Because the medical world is so compartmentalised it was some time before the connection between these increases was noticed and understood. There is now evidence that the simultaneous increase in these… 
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