Mycobacteria, metals, and the macrophage.

  title={Mycobacteria, metals, and the macrophage.},
  author={Olivier Neyrolles and Frank Wolschendorf and Avishek Mitra and Michael Niederweis},
  journal={Immunological reviews},
  volume={264 1},
Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ensure survival and replication inside the phagosome. Here, we describe the recent fascinating discoveries that the mammalian immune system responds to infections with M. tuberculosis by overloading the phagosome with copper and zinc, two metals which are essential nutrients in… CONTINUE READING


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