Myc translocations in B cell and plasma cell neoplasms.

  title={Myc translocations in B cell and plasma cell neoplasms.},
  author={Siegfried Janz},
  journal={DNA repair},
  volume={5 9-10},
Chromosomal translocations that join the cellular oncogene Myc (c-myc) with immunoglobulin (Ig) heavy-chain (Igh) or light-chain (Igk, Igl) loci are widely believed to be the crucial initiating oncogenic events in the development of B cell and plasma cell neoplasms in three mammalian species: Burkitt lymphoma (BL) in human beings, plasmacytoma (PCT) in mice, and immunocytoma in rats. Among the Myc-Ig translocations found in these neoplasms, mouse PCT T(12;15)(Igh-Myc) is of special interest… CONTINUE READING