Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.

@article{Zindy1998MycSV,
  title={Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.},
  author={Fr{\'e}d{\'e}rique Zindy and Christine M. Eischen and David H. Randle and Takehiko Kamijo and John L. Cleveland and Charles J Sherr and Martine F Roussel},
  journal={Genes & development},
  year={1998},
  volume={12 15},
  pages={2424-33}
}
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF and p53 gene expression in primary MEFs and triggers replicative crisis by inducing apoptosis. MEFs that survive myc overexpression sustain p53 mutation or ARF loss during the process of establishment and become immortal. MEFs lacking ARF or p53 exhibit an… CONTINUE READING
Highly Influential
This paper has highly influenced 36 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
447 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 447 extracted citations

Similar Papers

Loading similar papers…