Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

  title={Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling},
  author={M. F. Roussel and J. Cleveland and S. Shurtleff and C. Sherr},
  • M. F. Roussel, J. Cleveland, +1 author C. Sherr
  • Published 1991
  • Biology, Medicine
  • Nature
  • THE colony-stimulating factor-1 receptor (CSF-1 R) mediates its pleiotropic effects through the coupling of its ligand-activated tyrosine kinase to multiple intracellular effector proteins, whose combined actions determine the magnitude and specificity of the biological response. The interaction of cytoplasmic signalling molecules with CSF-1 R is mediated in part by sequence motifs flanking sites of receptor tyrosine phosphorylation1. Mutation of an autophosphorylation site at tyrosine 809 in… CONTINUE READING
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