Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.

@article{Bellosta2005MycIG,
  title={Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.},
  author={Paola Bellosta and Toby Hulf and Soda Balla Diop and Fabrice Usseglio and Jacques Pradel and Denise Aragnol and Peter Gallant},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 33},
  pages={11799-804}
}
The transcription factor dMyc is the sole Drosophila ortholog of the vertebrate c-myc protooncogenes and a central regulator of growth and cell-cycle progression during normal development. We have investigated the molecular basis of dMyc function by analyzing its interaction with the putative transcriptional cofactors Tip48/Reptin (Rept) and Tip49/Pontin (Pont). We demonstrate that Rept and Pont have conserved their ability to bind to Myc during evolution. All three proteins are required for… CONTINUE READING