Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins.

@article{Bouchard2004MycinducedPA,
  title={Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins.},
  author={Caroline Bouchard and Judith Marquardt and Alexandra Br{\'a}s and Ren{\'e} H Medema and Martin Eilers},
  journal={The EMBO journal},
  year={2004},
  volume={23 14},
  pages={2830-40}
}
Myc synergizes with Ras and PI3-kinase in cell transformation, yet the molecular basis for this behavior is poorly understood. We now show that Myc recruits TFIIH, P-TEFb and Mediator to the cyclin D2 and other target promoters, while the PI3-kinase pathway controls formation of the pre-initiation complex and loading of RNA polymerase II. The PI3-kinase pathway involves Akt-mediated phosphorylation of FoxO transcription factors. In a nonphosphorylated state, FoxO factors inhibit induction of… CONTINUE READING

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