Myc-driven endogenous cell competition in the early mammalian embryo

@article{Clavera2013MycdrivenEC,
  title={Myc-driven endogenous cell competition in the early mammalian embryo},
  author={C. Claver{\'i}a and G. Giovinazzo and Roc{\'i}o Sierra and M. Torres},
  journal={Nature},
  year={2013},
  volume={500},
  pages={39-44}
}
The epiblast is the mammalian embryonic tissue that contains the pluripotent stem cells that generate the whole embryo. We have established a method for inducing functional genetic mosaics in the mouse. Using this system, here we show that induction of a mosaic imbalance of Myc expression in the epiblast provokes the expansion of cells with higher Myc levels through the apoptotic elimination of cells with lower levels, without disrupting development. In contrast, homogeneous shifts in Myc… Expand
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