Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells

@inproceedings{Varlakhanova2011MycAM,
  title={Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells},
  author={Natalia V Varlakhanova and Rebecca F Cotterman and Keith R Bradnam and Ian F Korf and Paul S Knoepfler},
  booktitle={Epigenetics & Chromatin},
  year={2011}
}
A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important open topic. To test the hypothesis that the zinc finger protein Miz-1 plays a central role, in the present work we conducted chromatin immunoprecipitation/microarray (ChIP-chip) analysis of Myc and Miz-1 in human ES cells, finding homeobox (Hox) genes as the most significant functional class… CONTINUE READING
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