Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation

@inproceedings{Sun2015MycInducedLT,
  title={Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation},
  author={Lili Sun and Anh Tuan Nguyen and Jan M. Spitsbergen and Zhiyuan Gong},
  booktitle={PloS one},
  year={2015}
}
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of the two zebrafish myc genes. In the present study, we developed two transgenic zebrafish lines to over-express myca and mycb respectively in the liver using a… CONTINUE READING

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