Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.

  title={Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.},
  author={Abhishek Datta and Alo Nag and Wei Pan and Nissim Hay and Andrei L. Gartel and Oscar A. Colamonici and Yasuji Mori and Pradip Raychaudhuri},
  journal={The Journal of biological chemistry},
  volume={279 35},
The tumor suppressor protein ARF (alternate reading frame) inhibits MDM2 to stabilize and activate the functions of p53. Here we provide evidence for an additional activity of ARF that attenuates cell cycle progression independently of p53 activation. We show that ARF interacts with c-Myc independently of MDM2 or p53. Consequently, ARF relocalizes c-Myc from the nucleoplasm to the nucleolus. Binding and relocalization by ARF correlate with an inhibition of the c-Myc-activated transcription in… CONTINUE READING


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