Myc, Cdk2 and cellular senescence: Old players, new game.

  title={Myc, Cdk2 and cellular senescence: Old players, new game.},
  author={Stefano Campaner and Mirko Doni and Alessandro Verrecchia and Giovanni Fag{\'a} and Lucia Bianchi and Bruno Amati},
  journal={Cell cycle},
  volume={9 18},
The aberrant activation of oncogenic pathways promotes tumor progression, but concomitantly elicits compensatory tumor-suppressive responses, such as apoptosis or senescence. For example, Ras induces senescence, while Myc generally triggers apoptosis. Myc is in fact viewed as an anti-senescence oncogene, as it is a potent inducer of cell proliferation and immortalization, bypasses growth-inhibitory signals, and cooperates with Ras in cellular transformation. Recent reports prompt re-evaluation… CONTINUE READING

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