Myb-independent macrophages: a family of cells that develops with their tissue of residence and is involved in its homeostasis.

  title={Myb-independent macrophages: a family of cells that develops with their tissue of residence and is involved in its homeostasis.},
  author={Elisa Gomez Perdiguero and Fr{\'e}d{\'e}ric Geissmann},
  journal={Cold Spring Harbor symposia on quantitative biology},
In most metazoans, all tissues contain phagocytes "in residence," generally termed "macrophages" in vertebrates. In contrast to myeloid cells produced continuously by the bone marrow (BM), tissue-resident macrophages develop during embryogenesis together with their tissue of residence, and persist in adulthood, independently of hematopoietic stem cells and the transcription factor Myb. They therefore represent an independent lineage from blood monocytes, dendritic cells, and monocytes… 

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