Myasthenic crisis in the puerperium: the possible importance of α‐fetoprotein. Case report

@article{Hatada1987MyasthenicCI,
  title={Myasthenic crisis in the puerperium: the possible importance of $\alpha$‐fetoprotein. Case report},
  author={Yasuyuki Hatada and Masahide Munemura and I. Matsuo and Shunichi Fujisaki and Hitoshi Okamura and N Yamanaka},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={1987},
  volume={94}
}
The patient was a 27-ycar-old in her first pregnancy with mild systemic myasthenia gravis (Osserman classification IIA), with weakness, ptosis and diplopia since the age of 24. There was no significant gynaecological history. She was admitted at 37 weeks gestation for observation but had been in remission from 20 weeks, and had no exacerbation before delivery. In addition to anti-acetylcholine receptor (anti-AChR) antibody, she was also found to have antinuclear antibodies. The assessment of… 
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References

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TLDR
The study indicates a strong relationship between clinical course and AChR-ab in the individual patient when sustained improvement over 12 months and A chiral receptor antibody decreases greater than 50% are examined.
Inhibitory effect of alpha-fetoprotein on the binding of myasthenia gravis antibody to acetylcholine receptor.
TLDR
The binding of myasthenia gravis antibody acetylcholine receptor (AcChoR) as measured in vitro by Radioimmunoassay with 125I-labeled alpha-bungarotoxin (alpha-BuTx) suggests a similar effect in vivo in pregnant women with myast Hennessy gravis.
Antibody to acetylcholine receptor in myasthenia gravis
TLDR
Assay of antireceptor antibody should prove a useful test in the diagnosis of myasthenia gravis, and presence or titer of antibody did not appear to correlate with age, sex, steroid therapy, or duration of symptoms.
No direct correlation between serum antiacetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravis
Serum acetylcholine receptor antibodies were measured serially in myasthenia gravis patients before and after early extended thymectomy; they received no medication postoperatively. Clinical
Acetylcholine receptor antibody in the diagnosis of myasthenia gravis
TLDR
The role of AchR antibody assay in the diagnosis of ocular and generalized myasthenia gravis is reviewed, and compared to standard means of diagnosing the disease by clinical and electrophysiological methods.
Myasthenia Gravis
Prevalence, clinical correlates, and diagnostic value
  • Neurology