Myasthenia gravis seronegative for acetylcholine receptor antibodies.

  title={Myasthenia gravis seronegative for acetylcholine receptor antibodies.},
  author={Angela C Vincent and M. Isabel Leite and Maria Farrugia and Saiju Jacob and Stuart Viegas and Hiro Shiraishi and Olivier Benveniste and B. Paul Morgan and David Hilton-Jones and John Newsom-Davis and David Beeson and Nick Willcox},
  journal={Annals of the New York Academy of Sciences},
Antibodies to muscle-specific kinase (MuSK) are found in a variable proportion of patients with myasthenia without typical acetylcholine receptor (AChR) antibodies, but their characteristics and pathogenic mechanisms are not fully understood. We discuss the incidence and pathogenicity of MuSK antibodies and how clinical studies, animal models, and cultured cell lines can be used to elucidate their pathogenic mechanisms. Patients without either AChR or MuSK antibodies (seronegative myasthenia… CONTINUE READING