Myasthenia gravis after botulinum toxin a for Meige syndrome

@article{Tarsy2000MyastheniaGA,
  title={Myasthenia gravis after botulinum toxin a for Meige syndrome},
  author={D. Tarsy and N. Bhattacharyya and G. Borodic},
  journal={Movement Disorders},
  year={2000},
  volume={15}
}
Botulinum toxin A (BTX-A) produces muscle weakness by blocking presynaptic release of acetylcholine at the neuromuscular junction. Following treatment with usual clinical doses, weakness is limited to local or adjacent muscles without clinically important effects on muscles in other body regions. However, abnormal neuromuscular transmission and remote type II muscle atrophy 6 without clinical weakness have been identified in muscles remote from the site of BTX-A injection. Recently, several… Expand
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References

SHOWING 1-10 OF 18 REFERENCES
Systemic effect of local botulinum toxin injections unmasks subclinical Lambert-Eaton myasthenic syndrome.
TLDR
In the majority of studies and in the own series of more than 2000 local injections, no patient experienced weakness of remote muscles, but suggested an additional presynaptic disturbance of the neuromuscular junction, particularly Lambert-Eaton myasthenic syndrome (LEMS). Expand
Myasthenic crisis after botulinum toxin
TLDR
According to an 80-year-old woman previously injected with botulinum toxin for essential blepharospasm, her antiacetyl choline-receptor antibody produced an exaggerated and potentially life-threatening reaction to injectable botulinums toxin. Expand
Generalised botulism-like syndrome after intramuscular injections of botulinum toxin type A: a report of two cases.
TLDR
Two patients in whom treatment with therapeutic doses of BT/A resulted in a generalised muscle weakness with widespread EMG abnormalities which were typical of botulism are reported. Expand
Botulinum toxin for blepharospasm: single-fiber EMG studies
TLDR
In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles, indicating that the toxin spread remotely from the site of injection. Expand
Distant effects of local injection of botulinum toxin
TLDR
There is an effect on neuromuscular transmission in muscles distant to those injected with botulinum toxin for dystonia, and Jitter was maximally increased at slow firing rates, confirming its presynaptic basis. Expand
Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system.
To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patientsExpand
Muscle fiber atrophy in leg muscles after botulinum toxin type A treatment of cervical dystonia
TLDR
It is postulate that the observed atrophy is due to distant effects of botulinum toxin causing progressive denervation-like changes in non-treated muscle, and calls for further, prospective studies of the long-term effects of the treatment. Expand
Time course of distant effects of local injections of botulinum toxin
TLDR
There was no correlation between SFEMG findings and the dose of injected btx, and possible mechanisms for these observations may be either a very efficient local uptake and retrograde axonal transport via the spinal motor neurons or a systemic distribution via the blood circulation. Expand
Neuromuscular effects distant from the site of botulinum neurotoxin injection
TLDR
The effects observed are compatible with stimulation of terminal sprouting by the neurotoxin, without significant presynaptic inhibition of acetylcholine release, and believe that higher dosages of the neurot toxin may be used if clinically indicated. Expand
Myasthenia gravis. A clinical and basic science review.
TLDR
Myasthenia gravis is an autoimmune disorder caused by antibodies directed against the acetylcholine receptor of skeletal muscle that is likely to serve as the prototype for the understanding of more common organ-specific autoimmune disorders. Expand
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