Myasthenia gravis: clinical, immunological, and therapeutic advances
@article{Romi2005MyastheniaGC,
title={Myasthenia gravis: clinical, immunological, and therapeutic advances},
author={Fredrik Robert Romi and Nils Erik Gilhus and Johan A. Aarli},
journal={Acta Neurologica Scandinavica},
year={2005},
volume={111}
}We give an update on clinical, immunological, and therapeutic advances in the field of myasthenia gravis, including a summary of suggested therapeutic recommendations.
Topics from this paper
99 Citations
A clinical and immunological study of a myasthenia gravis patient treated with infliximab
- MedicineActa neurologica Scandinavica
- 2007
Clinical and immunological parameters in a patient with myasthenia gravis treated with antibodies against tumour necrosis factor‐alpha (infliximab, Remicade®) are measured.
Autoantibodies in acquired myasthenia gravis: Clinical phenotype and immunological correlation
- Medicine, BiologyActa neurologica Scandinavica
- 2019
Information on antibody profile in myasthenia gravis (MG) from India is limited and the need for further research into this subject is still being considered.
Treatment of a patient with myasthenia gravis using antibodies against CD25
- MedicineActa neurologica Scandinavica
- 2008
Clinical and immunological parameters in a patient with myasthenia gravis treated with antibodies against CD25 (basiliximab, Simulect®) are measured.
The effect of early prednisolone treatment on the generalization rate in ocular myasthenia gravis
- MedicineEuropean journal of neurology
- 2013
Several small retrospective studies have observed that patients with a purely ocular manifestation of myasthenia gravis (MG) are significantly less likely to convert to a generalized disease when…
Geographical distribution of A seropositive myasthenia gravis population
- MedicineMuscle & nerve
- 2012
To assess age‐ and sex‐specific myasthenia gravis (MG) occurrence and incidence in the different geographical regions in Norway and thereby to identify factors that may contribute to the development…
Paraneoplastic Neuromuscular Disorders
- Medicine, Psychology
- 2014
This chapter will focus on those paraneoplastic disorders that predominantly produce neuromuscular dysfunction and which are likely to be encountered in clinical practice.
Demyelinating disease in patients with myasthenia gravis.
- Medicine, BiologyArquivos de neuro-psiquiatria
- 2008
This work reports on three Brazilian patients with MG that presented distinct demyelinating diseases, two monophasic and one recurrent neuromyelitis optica, several years after the diagnosis of MG, and discusses their clinical courses.
Overlap of Myasthenia Gravis and Miller Fisher Syndrome.
- MedicineInternal medicine
- 2016
Although intravenous immunoglobulin therapy is effective for both diseases, two courses of the therapy did not improve the patient's symptoms, however, steroid therapy was effective.
Myasthenia Gravis in Enugu, South East Nigeria-Renewed Management Options
- Medicine
- 2017
Thymectomy has proven to be life saving in the management of Myasthenia Gravis in resource poor settings, saving patients from high cost of medications and general outcome of management of MG will greatly improve with diagnostic aids in low resource countries of the world.
Concurrent Guillain-Barré syndrome and myasthenia gravis: the first case in Taiwan.
- Biology, MedicineActa neurologica Taiwanica
- 2009
A case with the concurrent development of GBS and MG is presented and it is shown that thymoma-associated multi-organ autoimmunity may also play a role in initiating autoimmune process.
References
SHOWING 1-10 OF 106 REFERENCES
Successful treatment of refractory myasthenia gravis using rituximab: a pediatric case report.
- Medicine, PsychologyThe Journal of pediatrics
- 2003
We report the successful use of anti-CD20 therapy in a child with refractory myasthenia gravis (MG), an antibody-mediated autoimmune disease, who did not respond to conventional therapy. After…
Myasthenia gravis: diagnostic and management dilemmas
- Biology, MedicineCurrent opinion in neurology
- 2001
This review focuses on the diagnostic tests that may help to confirm myasthenia in patients without acetylcholine receptor antibodies, including the newly discovered anti-muscle-specific receptor…
Pathogenesis of myasthenia gravis.
- Medicine, BiologyBritish medical journal
- 1971
Preliminary studies by me of three thyroid patients showed reversal of hyperthyroidism on 15 mg daily of prednisone, and Steroid treatment of myasthenia gravis may be more effective if started sooner.
Immunoglobulin allotypes in myasthenia gravis patients with a thymoma.
- Medicine, BiologyJournal of autoimmunity
- 1990
Changes in peripheral blood lymphocyte subset frequencies in myasthenia gravis patients are related to immunosuppression
- Biology, MedicineJournal of Neurology
- 2004
Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the changes in peripheral blood lymphocyte subsets observed, however, immunosuppressive therapy correlated with the significant reduction in CD4+ and CD2+/CD4+ T cells in these patients.
Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review)
- MedicineNeurology
- 2000
The goal is to develop evidence-based recommendations for clinicians considering thymectomy for patients with nonthymomatous autoimmune MG by performing a systematic review and analysis of the literature.
The edrophonium test.
- MedicineSeminars in neurology
- 2003
The following review summarizes the history of edrophonium usage in myasthenia gravis, reviews the literature with regard to the method of performing the edroph onium test, and discusses the available information regarding sensitivity and specificity of the test with respect to diagnosis of MG.
Associated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy
- Medicine, BiologyActa neurologica Scandinavica
- 1989
The occurrence of autoimmune thyroiditis and systemic lupus erythematosus in the MG patients was clearly higher than that reported in the general population and the autoimmune diseases were mainly recorded among the nonthymectomized MG patients.
Plasma exchange in myasthenia gravis: effect on anti‐AChR antibodies and other autoantibodies
- Biology, MedicineActa neurologica Scandinavica
- 1986
The clinical improvement in patients with myasthenia gravis was maximal during the week after PE and correlated in time with increasing concentrations of AChR antibodies.