Myasthenia gravis: a clinical-immunological update

  title={Myasthenia gravis: a clinical-immunological update},
  author={Sophie Binks and Angela C Vincent and Jackie Palace},
  booktitle={Journal of Neurology},
Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. In most patients, IgG1-dominant antibodies to acetylcholine receptors cause fatigable weakness of skeletal muscles. In the rest, a variable proportion possesses antibodies to muscle-specific tyrosine kinase while the remainder of seronegative MG is being explained through cell-based assays using a receptor-clustering technique and, to a lesser extent, proposed new antigenic… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 5 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 20 extracted citations

[Myasthenic Crisis].

Fortschritte der Neurologie-Psychiatrie • 2018
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 111 references

Antibodies to clustered acetylcholine receptor: expanding the phenotype.

European journal of neurology • 2014
View 8 Excerpts
Highly Influenced

Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey.

Journal of the neurological sciences • 2011
View 7 Excerpts
Highly Influenced

Does Treatment of Ocular Myasthenia Gravis With Early Immunosuppressive Therapy Prevent Secondarily Generalization and Should It Be Offered to All Such Patients?

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society • 2016
View 13 Excerpts
Highly Influenced

The search for new antigenic targets in myasthenia gravis.

Annals of the New York Academy of Sciences • 2012
View 5 Excerpts
Highly Influenced

Evoli A (2011) Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts. Muscle Nerve

JT Guptill, DB Sanders
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…