MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10 deficient mice

@article{Hoshi2012MyD88SI,
  title={MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10 deficient mice},
  author={Namiko Hoshi and Dominik Schenten and Simone A Nish and Zenta Walther and Nicola Gagliani and Richard A. Flavell and Boris Reizis and Zeli Shen and James G. Fox and Akiko Iwasaki and Ruslan Medzhitov},
  journal={Nature communications},
  year={2012},
  volume={3},
  pages={1120 - 1120}
}
Commensal bacterial sensing by Toll-like receptors (TLRs) is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of IL-10. While TLRs are expressed in multiple cell types in the colon, the cell type(s) responsible for the development of colitis currently unknown. Here, we generated mice that are selectively deficient in MyD88 in various cellular compartments in an IL-10−/− setting. While epithelial expression of MyD88 was dispensable, MyD88 expression in the… 
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