MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

@article{Brandl2010MyD88SI,
  title={MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.},
  author={Katharina Brandl and Lei Sun and Christina Neppl and Owen M Siggs and Sylvain Le Gall and Wataru Tomisato and Xiaohong Li and Xin Du and Daniela N M{\"a}nnel and Carl P Blobel and Bruce Beutler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 46},
  pages={
          19967-72
        }
}
Toll-like receptors (TLRs) trigger intestinal inflammation when the epithelial barrier is breached by physical trauma or pathogenic microbes. Although it has been shown that TLR-mediated signals are ultimately protective in models of acute intestinal inflammation [such as dextran sulfate sodium (DSS)-induced colitis], it is less clear which cells mediate protection. Here we demonstrate that TLR signaling in the nonhematopoietic compartment confers protection in acute DSS-induced colitis… CONTINUE READING
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