MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.

@article{Bolz2004MyD88PA,
  title={MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.},
  author={Devin D Bolz and Rhianna S. Sundsbak and Ying Ma and Shizuo Akira and Carsten J Kirschning and James F. Zachary and John H. Weis and Janis J Weis},
  journal={Journal of immunology},
  year={2004},
  volume={173 3},
  pages={2003-10}
}
To assess the contribution of TLR signaling in the host response to Borrelia burgdorferi, mice deficient in the common TLR adaptor protein, myeloid differentiation factor 88 (MyD88), were infected with B. burgdorferi. MyD88-deficient mice harbored extremely high levels of B. burgdorferi in tissues when compared with wild-type littermates and greater amounts… CONTINUE READING