MyD88-dependent signals are essential for the host immune response in experimental brain abscess.

@article{Kielian2007MyD88dependentSA,
  title={MyD88-dependent signals are essential for the host immune response in experimental brain abscess.},
  author={Tammy Kielian and Nirmal K. Phulwani and Nilufer Esen and Mohsin Md Syed and Anessa C Haney and Kelly McCastlain and Jennifer Johnson},
  journal={Journal of immunology},
  year={2007},
  volume={178 7},
  pages={
          4528-37
        }
}
  • Tammy Kielian, Nirmal K. Phulwani, +4 authors Jennifer Johnson
  • Published in Journal of immunology 2007
  • Biology, Medicine
  • Brain abscesses form in response to a parenchymal infection by pyogenic bacteria, with Staphylococcus aureus representing a common etiologic agent of human disease. Numerous receptors that participate in immune responses to bacteria, including the majority of TLRs, the IL-1R, and the IL-18R, use a common adaptor molecule, MyD88, for transducing activation signals leading to proinflammatory mediator expression and immune effector functions. To delineate the importance of MyD88-dependent signals… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 69 REFERENCES

    Immunopathogenesis of brain abscess

    VIEW 10 EXCERPTS