MyD88-dependent autoimmune disease in Lyn-deficient mice.

  title={MyD88-dependent autoimmune disease in Lyn-deficient mice.},
  author={Karlee L Silver and Tanya L. Crockford and Tiphaine Bouriez-Jones and Simon Milling and Teresa Lambe and Richard J. Cornall},
  journal={European journal of immunology},
  volume={37 10},
Recent evidence suggests that systemic autoimmune disease depends on signals from TLR ligands, but little is known about how TLR-dependent pathways lead to the loss of self tolerance in vivo. To address this, we have examined the role of TLR signaling in Lyn-deficient mice, which develop an autoimmune disease similar to SLE. We found that absence of the TLR… CONTINUE READING