MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists.

Abstract

TLRs sense components of microorganisms and are critical host mediators of inflammation during infection. Different TLR agonists can profoundly alter inflammatory effects of one another, and studies suggest that the sequence of exposure to TLR agonists may importantly impact on responses during infection. We tested the hypothesis that synergy, priming, and… (More)

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