MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons.

@article{Tachado2010MyD88dependentTS,
  title={MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons.},
  author={Souvenir D. Tachado and Xin Mei Li and Medhavi Bole and Katharine A Swan and Asha M Anandaiah and Naimish R. Patel and Henry Koziel},
  journal={Blood},
  year={2010},
  volume={115 17},
  pages={
          3606-15
        }
}
Alveolar macrophages (AMs) are the predominant effector cell in the lungs and contribute to a critical first line of defense against bacterial pathogens through recognition by pattern recognition receptors such as Toll-like receptor 4 (TLR4). TLR4-mediated tumor necrosis factor alpha (TNFalpha) release is significantly impaired in HIV(+) macrophages, but whether HIV impairs myeloid differentiation factor 88 (MyD88)-dependent and/or MyD-independent TLR4 signaling pathways in human macrophages is… CONTINUE READING

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