MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.

@article{Wang2011MyD88dependentTS,
  title={MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.},
  author={Sen Wang and Eduardo J Villablanca and Jaime De Calisto and Daniel Cl{\'a}udio D E Oliviera Gomes and Deanna D. Nguyen and Emiko Mizoguchi and Jonathan C. Kagan and Hans-Christian Reinecker and Nir Hacohen and Cathryn Nagler and Ramnik J. Xavier and Bartira Rossi-Bergmann and Yi-Bin Chen and Rune Blomhoff and Scott B. Snapper and J Rodrigo Mora},
  journal={Journal of immunology},
  year={2011},
  volume={187 1},
  pages={141-50}
}
Gut-associated dendritic cells (DC) synthesize all-trans retinoic acid, which is required for inducing gut-tropic lymphocytes. Gut-associated DC from MyD88(-/-) mice, which lack most TLR signals, expressed low levels of retinal dehydrogenases (critical enzymes for all-trans retinoic acid biosynthesis) and were significantly impaired in their ability to induce gut-homing T cells. Pretreatment of extraintestinal DC with a TLR1/2 agonist was sufficient to induce retinal dehydrogenases and to… CONTINUE READING