MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4.

@article{Owens2011MyD88DA,
  title={MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4.},
  author={A Phillip Owens and Debra L. Rateri and Deborah A. Howatt and Kathryn J. Moore and Peter S. Tobias and Linda K. Curtiss and Hong Lu and Lisa A. Cassis and Alan Daugherty},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 12},
  pages={2813-9}
}
OBJECTIVE The purpose of this study was to determine whether myeloid differentiation factor 88 (MyD88) and its related Toll-like receptors (TLRs) 2 and 4 contributed to the development of angiotensin II (AngII)-induced abdominal aortic aneurysms (AAAs) and atherosclerosis. METHODS AND RESULTS AngII was infused into either apoE(-/-) or LDL receptor (LDLR)(-/-) male mice that were either MyD88(+/+) or (-/-). MyD88 deficiency profoundly reduced AngII-induced AAAs and atherosclerosis in both… CONTINUE READING

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