MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells.

@article{Villablanca2011MyD88AR,
  title={MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells.},
  author={Eduardo J Villablanca and Sen Wang and Jaime De Calisto and Daniel Cl{\'a}udio D E Oliviera Gomes and Maureen A. Kane and Joseph L Napoli and William S. Blaner and Hiroyuki Kagechika and Rune Blomhoff and Mario Rosemblatt and Mar{\'i}a Rosa Bono and Ulrich H von Andrian and J Rodrigo Mora},
  journal={Gastroenterology},
  year={2011},
  volume={141 1},
  pages={176-85}
}
BACKGROUND & AIMS Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting cells. We investigated whether RA functions in a positive-feedback loop in DC… CONTINUE READING