MyD88 Signaling in CD4 T Cells Promotes IFN-γ Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection

@article{Zhang2013MyD88SI,
  title={MyD88 Signaling in CD4 T Cells Promotes IFN-$\gamma$ Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection},
  author={Yubin Zhang and Maura Jones and Amanda McCabe and G. Winslow and D. Avram and K. MacNamara},
  journal={The Journal of Immunology},
  year={2013},
  volume={190},
  pages={4725 - 4735}
}
Hematopoietic stem and progenitor cell (HSPC) phenotype and function can change in response to infectious challenge. These changes can be mediated by cytokines, IFNs, and pathogen-associated molecules, via TLR, and are thought to promote tailored immune responses for particular pathogens. In this study, we investigated the signals that activate HSPCs during ehrlichiosis, a disease characterized by profound hematopoietic dysfunction in both humans and mice. In a mouse model of ehrlichiosis, we… Expand
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TLDR
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