MyD88: a central player in innate immune signaling

  title={MyD88: a central player in innate immune signaling},
  author={Jacques Deguine and Gregory M. Barton},
  booktitle={F1000prime reports},
MyD88 is the canonical adaptor for inflammatory signaling pathways downstream of members of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families. MyD88 links IL-1 receptor (IL-1R) or TLR family members to IL-1R-associated kinase (IRAK) family kinases via homotypic protein-protein interaction. Activation of IRAK family kinases leads to a variety of functional outputs, including the activation of nuclear factor-kappa B (NFκB), mitogen-activated protein kinases, and activator… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 42 extracted citations


Publications referenced by this paper.
Showing 1-10 of 67 references

Page 6 of 7 (page number not for citation purposes) F1000Prime Reports

K Tabeta, K Hoebe, +10 authors DA Portnoy
Nat Immunol • 2006
View 10 Excerpts
Highly Influenced

High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites

W Kraan, HM Horlings, +7 authors ST Pals
Blood Cancer J 2013, • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…