MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease.

@article{Heimesaat2010MyD88TLR9MI,
  title={MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease.},
  author={Markus M Heimesaat and A. Nogai and Stefan Bereswill and Rita Plickert and Andre L. Fischer and Christoph Loddenkemper and Ulrich Steinhoff and Sandrine Y Tchaptchet and Agnieszka Korfel and Marina A. Freudenberg and Ulf Berthold G{\"o}bel and Lutz Uharek},
  journal={Gut},
  year={2010},
  volume={59 8},
  pages={
          1079-87
        }
}
BACKGROUND The bacterial microflora aggravates graft-versus-host-disease (GvHD) after allogeneic stem cell transplantation, but the underlying mechanisms of manifestations of intestinal GvHD (iGvHD) in the gut remain poorly understood. AIM To analyse the gut flora composition and the impact of bacterial sensing via Toll-like receptors (TLRs) in iGvHD. METHODS By mimicking clinical low-intensity conditioning regimens used in humans, a novel irradiation independent, treosulfan and… CONTINUE READING
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