My treatment approach to hairy cell leukemia.

  title={My treatment approach to hairy cell leukemia.},
  author={Rahul R Naik and Alan Saven},
  journal={Mayo Clinic proceedings},
  volume={87 1},
Hairy cell leukemia (HCL) is a rare chronic lymphoproliferative disorder characterized by circulating B cells with cytoplasmic projections, pancytopenia, splenomegaly, and a typical flow cytometry pattern. Recently, the BRAF V600E mutation was uniformly identified in one HCL series, which may provide insights into the pathogenic mechanisms. The disease course is usually indolent but inexorably progressive. Patients require treatment when they have significant cytopenia or occasionally recurrent… CONTINUE READING