MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.

@article{Opp2015MxBIN,
  title={MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.},
  author={Silvana Opp and Daniel A. S. A. Vieira and Bianca Schulte and Sumit K. Chanda and Felipe D{\'i}az-Griffero},
  journal={Journal of virology},
  year={2015},
  volume={90 6},
  pages={3056-64}
}
UNLABELLED MxB restricts HIV-1 infection by directly interacting with the HIV-1 core, which is made of viral capsid; however, the contribution of MxB to the HIV-1 restriction observed in alpha interferon (IFN-α)-treated human cells is unknown. To understand this contribution, we used HIV-1 bearing the G208R capsid mutant (HIV-1-G208R), which overcomes the restriction imposed by cells expressing MxB. Here we showed that the reason why MxB does not block HIV-1-G208R is that MxB does not interact… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 33 references

The interferon-inducible MxB protein inhibits HIV-1 infection.

Cell host & microbe • 2013
View 5 Excerpts
Highly Influenced

Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2011
View 16 Excerpts
Highly Influenced

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