Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales.

  title={Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales.},
  author={Benjamin A. Braun and Amir Marcovitz and J Gray Camp and Robin Jia and Gill Bejerano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 26},
Viral outbreaks in dolphins and other Delphinoidea family members warrant investigation into the integrity of the cetacean immune system. The dynamin-like GTPase genes Myxovirus 1 (Mx1) and Mx2 defend mammals against a broad range of viral infections. Loss of Mx1 function in human and mice enhances infectivity by multiple RNA and DNA viruses, including orthomyxoviruses (influenza A), paramyxoviruses (measles), and hepadnaviruses (hepatitis B), whereas loss of Mx2 function leads to decreased… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 65 times. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 52 references

Wholegenome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of polymorphisms under extreme population bottleneck

N Osada, N Hettiarachchi, I Adeyemi Babarinde, N Saitou, A Blancher
Genome Biol Evol 7(3):821–830 • 2015

A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection

JM Ciencewicki
FASEB J • 2014

A phylogenetic blueprint for a modern whale.

Molecular phylogenetics and evolution • 2013

Similar Papers

Loading similar papers…