Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

  title={Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release},
  author={Emilie V{\'e}n{\'e}reau and Maura Casalgrandi and Milena Schiraldi and Daniel J Antoine and Angela Cattaneo and Francesco de Marchis and Jaron Liu and Antonella Antonelli and Alessandro Preti and Lorenzo Raeli and Sara Samadi Shams and H. -S. Yang and Luca Varani and Ulf Andersson and Kevin J Tracey and Angela Bachi and Mariagrazia Uguccioni and Marco Emilio Bianchi},
  booktitle={The Journal of experimental medicine},
Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas a disulfide bond makes it a proinflammatory cytokine and further cysteine oxidation to sulfonates by reactive oxygen species abrogates both activities. We show that leukocyte recruitment and… CONTINUE READING
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Reflex principles of immunological homeostasis

  • A. C. Aveberger, H. Erlandsson-Harris
  • Annu . Rev . Immunol .
  • 2012

Therapeutic potential of high

  • G. Ghirlanda, A. Flex
  • 2011
1 Excerpt

Therapeutic potential of high mobility group box1 in ischemic injury and tissue regeneration

  • S. Carta, L. Delfino, S. Tassi, R. Venè
  • Curr . Vasc . Pharmacol .
  • 2011

A critical

  • B. Lu, S. Chavan, M. Rosas-Ballina, Y. Al-Abed
  • 2010

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