Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

@inproceedings{Vnreau2012MutuallyER,
  title={Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release},
  author={Emilie V{\'e}n{\'e}reau and Maura Casalgrandi and Milena Schiraldi and Daniel J Antoine and Angela Cattaneo and Francesco de Marchis and Jaron Liu and Antonella Antonelli and Alessandro Preti and Lorenzo Raeli and Sara Samadi Shams and H. -S. Yang and Luca Varani and Ulf Andersson and Kevin J Tracey and Angela Bachi and Mariagrazia Uguccioni and Marco Emilio Bianchi},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas a disulfide bond makes it a proinflammatory cytokine and further cysteine oxidation to sulfonates by reactive oxygen species abrogates both activities. We show that leukocyte recruitment and… CONTINUE READING
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