Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.

@article{Mao2004MutuallyEM,
  title={Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.},
  author={J R Mao and Minh To and Jesus Perez-losada and Di Wu and Reyno Del Rosario and Allan Balmain},
  journal={Genes & development},
  year={2004},
  volume={18 15},
  pages={1800-5}
}
Pten heterozygous (Pten+/-) mice develop increased papilloma numbers and show decreased carcinoma latency time in comparison with controls after skin treatment with dimethyl benzanthracene (DMBA) and tetradecanoyl-phorbol acetate (TPA). H-ras mutation is normally a hallmark of DMBA-TPA-induced skin tumors, but 70% of carcinomas from Pten+/- mice do not… CONTINUE READING