Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

@article{Ellmeier1992MutuallyEE,
  title={Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.},
  author={Wilfried Ellmeier and Adriano Aguzzi and E. Kleiner and Robert Kurzbauer and Andreas Weith},
  journal={The EMBO journal},
  year={1992},
  volume={11 7},
  pages={2563-71}
}
We have isolated a novel human gene encoding a helix-loop-helix (HLH) protein by molecularly cloning chromosome 1p36-specific CpG islands. The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12. Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins. Heir-1 does not encode a basic DNA binding domain as found in basic HLH proteins. The gene is expressed specifically at high… CONTINUE READING