Mutual regulation of cyclin-dependent kinase and the mitotic exit network

@inproceedings{Knig2010MutualRO,
  title={Mutual regulation of cyclin-dependent kinase and the mitotic exit network},
  author={Cornelia K{\"o}nig and Hiromi Maekawa and Elmar Schiebel},
  booktitle={The Journal of cell biology},
  year={2010}
}
The mitotic exit network (MEN) is a spindle pole body (SPB)-associated, GTPase-driven signaling cascade that controls mitotic exit. The inhibitory Bfa1-Bub2 GTPase-activating protein (GAP) only associates with the daughter SPB (dSPB), raising the question as to how the MEN is regulated on the mother SPB (mSPB). Here, we show mutual regulation of cyclin-dependent kinase 1 (Cdk1) and the MEN. In early anaphase Cdk1 becomes recruited to the mSPB depending on the activity of the MEN kinase Cdc15… CONTINUE READING
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